Fraser Lab

The Fraser Lab uses large-scale systematic surveys of gene function to gain insights into basic biology.

For many years we used C. elegans as a beautiful simple model system to try to understand how much of complex animal biology can be predicted from those kind of systematic approaches. This work included the first genome-scale RNAi screens (as a postdoc), the first systematic animal genetic interaction map, and analysis of the effect of genetic background on loss of function phenotypes as well as key collaborative work to show that whole animal loss of function phenotypes can be accurately predicted by integrating large-scale functional genomics datasets. Our current work aims to harness the incredible power of DNA sequencing to revolutionise the detection and measurement of metabolites and drugs. We believe strongly that science is highly collaborative and love using new genomics-scale technologies to explore biology in a systematic way.

Click to see a description of our current work