THE FRASER LAB USES SYSTEMATIC APPROACHES IN C.ELEGANS TO PROBE BASIC PROBLEMS IN GENETICS.
We ask questions like:
• Can we predict the effect of any single mutation on the phenotype of an entire animal?
• Can we predict how pairs of mutations combine to affect the phenotype?
• Can we understand how genetic background affects the severity and penetrance of Mendelian disorders?
In all these cases, we use the power of systematic genetics in the worm to answer questions that are key in human genetics — how does any mutation affect health and disease and how do the precise combination of variants in your personal genome alter the severity of the impact any disease-causing mutation?