Former Post Doc
During his tenure in the lab, Mark developed and lead projects in Drug Screening, Computer Image Analysis, and Technology Development. After leaving the lab, Mark has started his own company, Phenalysys, to further develop his image analysis technology and perform contract work.
Rhodoquinone biosynthesis in C. elegans requires precursors generated by the kynurenine pathway.
Del Borrello S, Lautens M, Dolan K, Tan JH, Davie T, Schertzberg MR, Spensley MA, Caudy AA, Fraser AG.
Elife. 2019 Jun 24;8. pii: e48165.
Acute Effects of Drugs on Caenorhabditis elegans Movement Reveal Complex Responses and Plasticity.
Spensley M, Del Borrello S, Pajkic D, Fraser AG.
G3 (Bethesda). 2018 Aug 30;8(9):2941-2952.
Natural Variation in Gene Expression Modulates the Severity of Mutant Phenotypes.
Vu V, Verster AJ, Schertzberg M, Chuluunbaatar T, Spensley M, Pajkic D, Hart GT, Moffat J, Fraser AG.
Cell. 2015 Jul 16;162(2):391-402.
A high quality Arabidopsis transcriptome for accurate transcript-level analysis of alternative splicing. Zhang R, Calixto CPG, Marquez Y, Venhuizen P, Tzioutziou NA, Guo W, Spensley M, Entizne JC, Lewandowska D, Ten Have S, Frei Dit Frey N, Hirt H, James AB, Nimmo HG, Barta A, Kalyna M, Brown JWS. Nucleic Acids Res. 2017 May 19;45(9):5061-5073.
Plant U13 orthologues and orphan snoRNAs identified by RNomics of RNA from Arabidopsis nucleoli. Kim SH, Spensley M, Choi SK, Calixto CP, Pendle AF, Koroleva O, Shaw PJ, Brown JW. Nucleic Acids Res. 2010 May;38(9):3054-67.
Evolutionarily conserved regulatory motifs in the promoter of the Arabidopsis clock gene LATE ELONGATED HYPOCOTYL. Spensley M, Kim JY, Picot E, Reid J, Ott S, Helliwell C, Carré IA. Plant Cell. 2009 Sep;21(9):2606-23.