Samantha Del Borrello
Samantha works on using C. elegans as a model for the discovery of new drugs to kill parasitic worms. She tricks our harmless laboratory worms into using metabolic pathways similar to those of parasites when it's within a host's hypoxic environment. She then tries to prevent them from surviving in these conditions with various compounds. Whether it be a new molecule or the repurposing of an existing drug, Samantha will test it in our system. So far she has some interesting leads, so keep an eye out for publications with her name on them!
Rhodoquinone biosynthesis in C. elegans requires precursors generated by the kynurenine pathway.
Del Borrello S, Lautens M, Dolan K, Tan JH, Davie T, Schertzberg MR, Spensley MA, Caudy AA, Fraser AG.
Elife. 2019 Jun 24;8. pii: e48165.
Acute Effects of Drugs on Caenorhabditis elegans Movement Reveal Complex Responses and Plasticity.
Spensley M, Del Borrello S, Pajkic D, Fraser AG.
G3 (Bethesda). 2018 Aug 30;8(9):2941-2952.
H.BSc : University of Toronto
3D printing, plants, puzzles, [un]planned alliteration